Medicinal Chemistry

Adamantyl Analogues of Paracetamol as Potent Analgesic Drugs via Inhibition of TRPA1

Chemistry / Medicinal Chemistry / Pain / Drug Discovery / Ion Channels / TRPV1 / Ibuprofen / Acetaminophen / Trpa1 / TRPV1 / Ibuprofen / Acetaminophen / Trpa1

Inhibition of Plasmepsin V Activity Demonstrates Its Essential Role in Protein Export, PfEMP1 Display, and Survival of Malaria Parasites

Microbiology / Medicinal Chemistry / Molecular Biology / Biology / Malaria / Enzyme Inhibitors / Public Health / Protease / Host Parasite Interaction / Enzyme Inhibitors / Public Health / Protease / Host Parasite Interaction

In vitro and in vivo profile of 5-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity

Organic Chemistry / Medicinal Chemistry / Obesity / Pharmacokinetics / Pharmaceutical Chemistry / Dogs / Cell line / In Vitro / Humans / Models / Animals / Drug Design / Enzyme / Food intake / In Vivo / Rats / Rat / Carboxylic Acids / Molecular Conformation / Bioorganic and medicinal Chemistry / Hydrogen-Ion Concentration / Chemical Synthesis / Carbamates / Selectivity / Dogs / Cell line / In Vitro / Humans / Models / Animals / Drug Design / Enzyme / Food intake / In Vivo / Rats / Rat / Carboxylic Acids / Molecular Conformation / Bioorganic and medicinal Chemistry / Hydrogen-Ion Concentration / Chemical Synthesis / Carbamates / Selectivity

Cinnamic Anilides as New Mitochondrial Permeability Transition Pore Inhibitors Endowed with Ischemia-Reperfusion Injury Protective Effect in Vivo

Organic Chemistry / Medicinal Chemistry / Calcium / Female / Animals / Male / Myocardial Infarction / Rabbits / Structure activity Relationship / Male / Myocardial Infarction / Rabbits / Structure activity Relationship

Novel tetracyclic spiropiperidines. 3. 1-Arylspiro[indoline-3,4\'-piperidine]s as potential antidepressants

Organic Chemistry / Medicinal Chemistry / Humans / Animals / Medicinal / Structure activity Relationship / Biological Assay / Piperidines / Tetrabenazine / Structure activity Relationship / Biological Assay / Piperidines / Tetrabenazine

Siderophores as \"Trojan Horses\": tackling multidrug resistance?

Organic Chemistry / Medicinal Chemistry / Siderophores / Peptides / Gram-negative bacteria / Microbial Sensitivity Tests / Beta Lactamases / Microbial Sensitivity Tests / Beta Lactamases

FRANCISCO VARELA: NEUROFENOMENOLOGÍA , ENFOQUE ENACTIVO DE LA COGNICIÓN, MENTES SIN YO Y EL ELUSIVO FENÓMENO DE LA CONCIENCIA

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Neurochemistry / Cognitive Neuropsychology / Consciousness / Affective Neuroscience / Neuroethics / Medical Ethics / Giorgio Agamben / Cultural Identity / Placebo Effect / Social Neuroscience / Metaphysics of Mind / Subjectivity (Identity Politics) / Self-Knowledge / Michel Foucault / Dopaminergic Neurotransmision / Language and Identity / Philosophy of Logic / Neurolinguistics / Nietzsche / Peter Sloterdijk / Nihilism / Neurophenomenology / Biopolitics / Biodiversity / Heidegger / Theory of Mind (Psychology) / Gregory Bateson / Drug Delivery System / Cognitive Neuroscience / Neurophysiology / Cultural Anthropology / Dreams / Neurobiology / Enaction (Psychology) / Medicine / Francisco Varela / Behavioral Neuroscience / Knowledge-How / Contemporary Philosophy / Mind Mapping / Neuroplasticity / Estudios Culturales / Biological Sciences / Biodiversity Conservation / Clinical Pharmacy / Artificial Neural Networks / Subjectivity / Ciencia Politica / PSICOLOGIA ORGANIZACIONAL / Meditation / 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Varela and neurophenomenology / Filosofía francesa contemporánea / Pensamiento sistémico / Self Representation / Budismo / Filosofia contemporânea / Ciencias Naturales / Antropology of Art / Facultad de Psicología / Psicologia Clinica / Anthropology of Religion / Gestão Da Mente / Redes Neuronales Artificiales / Neurociencias cognitivas / Neurology and Psychiatry / Zen Budismo / Dr. Adolfo Vásquez Rocca / Revista Observaciones Filosóficas / Psicologia Industrial Organizacional / Teoría de la Mente / Ciencias Cognitivas / Psicologia ambiental y organizacional / Psychology of Literature and Arts / Subjetividade deEducação SIRSSE / Filosofía Alemana Contemporánea / Psicologia / Foucault / Psicologia Organizacional E Do Trabalho / Psicología Organizacional / Matriztica

Synthetic Peptides Reproducing Tissue Transglutaminase–Gliadin Complex Neo-epitopes as Probes for Antibody Detection in Celiac Disease Patients’ Sera

Organic Chemistry / Medicinal Chemistry / Adolescent / Antibodies / Humans / Child / Celiac Disease / Gliadin / Female / Male / Young Adult / Peptides / Adult / Epitopes / Gtp Binding Proteins / Transglutaminases / Child / Celiac Disease / Gliadin / Female / Male / Young Adult / Peptides / Adult / Epitopes / Gtp Binding Proteins / Transglutaminases

Novel Conjugated Quinoline–Indoles Compromise Plasmodium falciparum Mitochondrial Function and Show Promising Antimalarial Activity

Organic Chemistry / Medicinal Chemistry / Mitochondria / Humans / Drug Resistance / Plasmodium falciparum / Antimalarials / Chloroquine / Structure activity Relationship / Hemoglobins / Plasmodium falciparum / Antimalarials / Chloroquine / Structure activity Relationship / Hemoglobins

Characterization of a Designed Vascular Endothelial Growth Factor Receptor Antagonist Helical Peptide with Antiangiogenic Activity in Vivo

Organic Chemistry / Water / Medicinal Chemistry / Magnetic Resonance Spectroscopy / Signal Transduction / Humans / Endothelial Cells / Circular Dichroism / Mice / Animals / Peptides / Protein Secondary Structure Prediction / Medicinal / Cell Proliferation / Cell Survival / Humans / Endothelial Cells / Circular Dichroism / Mice / Animals / Peptides / Protein Secondary Structure Prediction / Medicinal / Cell Proliferation / Cell Survival

Characterization of a Designed Vascular Endothelial Growth Factor Receptor Antagonist Helical Peptide with Antiangiogenic Activity in Vivo

Organic Chemistry / Water / Medicinal Chemistry / Magnetic Resonance Spectroscopy / Signal Transduction / Humans / Endothelial Cells / Circular Dichroism / Mice / Animals / Peptides / Protein Secondary Structure Prediction / Medicinal / Cell Proliferation / Cell Survival / Humans / Endothelial Cells / Circular Dichroism / Mice / Animals / Peptides / Protein Secondary Structure Prediction / Medicinal / Cell Proliferation / Cell Survival

Preparation and Pharmacological Characterization of trans -2-Amino-5(6)-fluoro-6(5)-hydroxy-1-phenyl-2,3-dihydro-1 H -indenes as D 2 -like Dopamine Receptor Agonists

Organic Chemistry / Medicinal Chemistry / cyclic AMP / Animals / dopamine receptor D4 / Rats / Swine / Radioligand Assay / Medicinal / Structure activity Relationship / cyclic GMP / Rats / Swine / Radioligand Assay / Medicinal / Structure activity Relationship / cyclic GMP
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